Two Novel Tyrosinase Inhibitory Sesquiterpenes Induced by CuCl2 from a Marine-Derived Fungus Pestalotiopsis sp. Z233.

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Wu, Bin, Wu, Xiaodan, Sun, Min and Li, Minhui (2013) Two Novel Tyrosinase Inhibitory Sesquiterpenes Induced by CuCl2 from a Marine-Derived Fungus Pestalotiopsis sp. Z233. Open Access Marine Drugs, 11 (8). pp. 2713-2721. DOI 10.3390/md11082713.

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Abstract

Two new sesquiterpenes, 1β,5α,6α,14-tetraacetoxy-9α-benzoyloxy-7β H-eudesman-2β,11-diol (1) and 4α,5α-diacetoxy-9α-benzoyloxy-7βH-eudesman-1β,2β,11, 14-tetraol (2), were produced as stress metabolites in the cultured mycelia of Pestalotiopsis sp. Z233 isolated from the algae Sargassum horneri in response to abiotic stress elicitation by CuCl2. Their structures were established by spectroscopic means. New compounds 1 and 2 showed tyrosinase inhibitory activities with IC50 value of 14.8 µM and 22.3 µM

Document Type: Article
Keywords: sesquiterpenes; Pestalotiopsis sp.; abiotic stress; tyrosinase inhibitory activities
Research affiliation: OceanRep > GEOMAR > FB3 Marine Ecology > FB3-MI Marine Microbiology
Refereed: Yes
Open Access Journal?: Yes
Publisher: MDPI
Date Deposited: 10 Dec 2013 12:47
Last Modified: 02 Mar 2018 12:54
URI: https://oceanrep.geomar.de/id/eprint/22595

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