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Scopularides A and B, cyclodepsipeptides from a marine sponge-derived fungus Scopulariopsis brevicaulis.
Zhiguo, Yu, Lang, Gerhard, Kajahn, Inga, Schmaljohann, Rolf and Imhoff, Johannes F.
(2008)
Scopularides A and B, cyclodepsipeptides from a marine sponge-derived fungus Scopulariopsis brevicaulis.
Journal of Natural Products, 71
.
pp. 1052-1054.
DOI 10.1021/np070580e.
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164_Zhiguo_2008_ScopularidesAAndBCyclodepsipeptides_Artzeit_pubid9712.pdf - Published Version Restricted to Registered users only Download (67kB) |
Abstract
Two novel cyclodepsipeptides, scopularides A and B, were found in the fungus Scopulariopsis brevicaulis, which was isolated from the marine sponge Tethya aurantium. In addition, the known fungal metabolite paxilline was identified. The structures of the scopularides were elucidated by NMR, MS, and chemical derivatization methods as cyclo-(3-hydroxy-4-methyldecanoyl−Gly−l-Val−d-Leu−l-Ala−l-Phe) and cyclo-(3-hydroxy-4-methyloctanoyl−Gly−l-Val−d-Leu−l-Ala−l-Phe) for scopularide A and B, respectively. Antibiotic activity against Gram-negative bacteria was absent and against Gram-positive bacteria was weak, but activity against several tumor cell lines was significant at 10 µg/mL.
Document Type: | Article |
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Research affiliation: | OceanRep > GEOMAR > FB3 Marine Ecology > FB3-MI Marine Microbiology OceanRep > GEOMAR > Applied R&D > Centre for Marine Substances (KiWiZ) |
Refereed: | Yes |
Open Access Journal?: | No |
Publisher: | ACS (American Chemical Society) |
Projects: | KIWIZ, Future Ocean |
Date Deposited: | 03 Dec 2008 16:52 |
Last Modified: | 17 Oct 2019 07:10 |
URI: | https://oceanrep.geomar.de/id/eprint/3197 |
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