Cheng, Cheng, Othman, Eman M., Fekete, Agnes, Krischke, Markus, Stopper, Helga, Edrada-Ebel, RuAngelie, Mueller, Martin J., Hentschel, Ute and Abdelmohsen, Usama Ramadan (2016) Strepoxazine A, a new cytotoxic phenoxazin from the marine sponge-derived bacterium Streptomyces sp. SBT345. Tetrahedron Letters, 57 (37). pp. 4196-4199. DOI 10.1016/j.tetlet.2016.08.005.

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Abstract

Highlights

• One new phenoxazin analogue, strepoxazine A was identified from the solid culture of Streptomyces sp. SBT345.
• Additionally, two known phenazine compounds phencomycin and tubermycin B were also reported.
• Strepoxazine A (1) showed antiproliferative activity against leukaemia cells HL-60.

Abstract

One new phenoxazin analogue, strepoxazine A (1), along with two known antibiotic phenazines phencomycin (2) and tubermycin B (3) were isolated from the solid culture of Streptomyces sp. SBT345 which had previously been recovered from the Mediterranean sponge Agelas oroides. The structures of compounds 1, 2 and 3 were determined by spectroscopic analyses including 1D and 2D NMR, and HR-ESI-MS experiments as well as comparison to the literature. We further investigated the apoptotic effect of the three compounds on the human promyelocytic leukaemia cells HL-60 and human breast adenocarcinoma cells MCF-7. Only strepoxazine A (1) showed cytotoxicity against leukaemia cells HL-60 cells. These results demonstrate that sponge-associated actinomycetes are rich sources for natural products with new pharmacological activities and relevance to drug discovery.

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