Wiese, Jutta , Abdelmohsen, Usama Ramadan, Motiei, Asa, Hentschel, Ute and Imhoff, Johannes F. (2018) Bacicyclin, a new antibacterial cyclic hexapeptide from Bacillus sp. strain BC028 isolated from Mytilus edulis. Bioorganic & Medicinal Chemistry Letters, 28 (4). pp. 558-561. DOI 10.1016/j.bmcl.2018.01.062.

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Abstract

A new cyclic hexapeptide, cyclo-(Gly-Leu-Val-IIe-Ala-Phe), named bacicyclin (1), was isolated from a marine Bacillus sp. strain associated with Mytilus edulis. The sequences of the amino acid building blocks of the cyclic peptide and its structure were determined by 1D- and 2D-NMR techniques. Marfey's analysis showed that the amino acid building blocks had L-configuration in all cases except for alanine and phenylalanine, which had D-configuration. Bacicyclin (1) exhibited antibacterial activity against the clinically relevant strains Enterococcus faecalis and Staphylococcus aureus with minimal inhibitory concentration values of 8 and 12 μM, respectively. These results demonstrate the potential of marine bacteria as a promising source for the discovery of new antibiotics.

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