Structures and biological activities of cycloheptamycins A and B.

Tools

Qian, Zhengyi, Antosch, Janine, Wiese, Jutta , Imhoff, Johannes F. , Fiedler, Hans-Peter, Pöthig, Alexander and Gulder, Tobias A. M. (2019) Structures and biological activities of cycloheptamycins A and B. Organic & Biomolecular Chemistry, 17 (27). pp. 6595-6600. DOI 10.1039/c9ob01261c.

[thumbnail of Qian.pdf] Text
Qian.pdf - Reprinted Version
Restricted to Registered users only
Download (1MB) | Contact
[thumbnail of Qian_Sppl_data.pdf] Text
Qian_Sppl_data.pdf - Reprinted Version
Restricted to Registered users only
Download (5MB) | Contact

Supplementary data:

Abstract

The heptadepsipeptide cycloheptamycin A was isolated from the terrestrial Streptomyces sp. Tü 6314. Its constitution was elucidated on the basis of NMR spectroscopic experiments and mass spectrometric analysis. Its stereostructure was investigated by peptide hydrolysis and derivatization and firmly established by X-ray structure analysis. In addition to the parent compound, a new cycloheptamycin analog, cycloheptamycin B, was discovered and structurally assigned using comparative MS/MS experiments and NMR. The biological profile of both compounds was investigated, revealing a selective inhibitory potential of cycloheptamycins against Propionibacterium acnes.

Document Type: Article
Research affiliation: OceanRep > GEOMAR > FB3 Marine Ecology > FB3-MS Marine Symbioses
Refereed: Yes
Open Access Journal?: No
Publisher: Royal Society of Chemistry
Date Deposited: 03 Jul 2019 09:56
Last Modified: 31 Jan 2022 09:16
URI: https://oceanrep.geomar.de/id/eprint/47095

Actions (login required)

View Item View Item